Description
Kisspeptin (a.k.a. metastin) is a naturally occurring protein in humans that plays important roles in hormone signaling during puberty and reproduction. It is also thought to alter mood and behavior, promote angiogenesis, and regulate kidney function. The peptide has also been found in the brain and is known to suppress tumor growth and metastasis (spread). The peptide is of greatest scientific interest for its ability to influence gonadotropin releasing hormone (GnRH).
Product Usage
This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.
Benefits of Kisspeptin
- Boosts Gonadotropin-Releasing Hormone: Enhances the release of FSH and LH, driving puberty and gamete maturation.
- Increases Testosterone Levels: Significantly raises testosterone levels in men.
- Regulates Energy Balance: Influences energy expenditure and adiposity.
- Suppresses Cancer Metastasis: Reduces cancer cell migration and adhesion.
- Enhances Memory: Improves memory consolidation and orientation in 3-D space.
- Improves Mood: Increases reward-seeking behavior, drive, and overall mood.
- Supports Kidney Function: Plays a role in glomerular development and vascular response in the kidney.
- Aids Cardiovascular Health: Controls vasoconstriction and cardiac output, influencing vascular function.
- Reduces Inflammation: Decreases ectopic fat deposition and inflammation.
- FDA Approved for Specific Treatments: Recognized for specific therapeutic uses, such as HIV-associated lipodystrophy.
Structure of Kisspeptin Peptide
Sequence: YNWNSFGLRF
Molecular Formula: C63H83N17O14
Molecular Weight: 1302.4 g/mol
PubChem CID: 25240297
CAS Number: KISS-1, Protein KISS-1, metastin, Kp-10 peptide
Research Findings on Kisspeptin
Boosting Gonadotropin-Releasing Hormone
Gonadotropin-releasing hormone (GnRH) is synthesized and released from neurons in the hypothalamus. It controls the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland, driving puberty and gamete maturation. Therapeutically, GnRH is used to control menstruation, treat precocious puberty, and as a continuous infusion in certain cancers.
Increasing Testosterone
Kisspeptin affects circulating levels of LH and FSH, altering testosterone levels, especially in men. In a study, six men administered kisspeptin showed a nearly threefold increase in plasma testosterone levels after 90 minutes. Another analog of kisspeptin alters LH pulse frequency, enhancing the pulsatile release of sex hormones, opening potential uses for kisspeptin in various settings from pregnancy to low testosterone.
Energy Balance
Kisspeptin neurons are sensitive to an individual’s energy status. Both under-nutrition and severe over-nutrition can blunt kisspeptin’s action in stimulating GnRH release, leading to infertility. Kisspeptin may also regulate energy balance, as observed in mice lacking the kisspeptin receptor, which showed increased adiposity and reduced energy expenditure.
Cancer Research
Kisspeptin can suppress melanoma metastasis by reducing cancer cell migration. It may also reduce cell adhesion, preventing cancer cells from invading other tissues. Various metastatic cancers show changes in kisspeptin levels, suggesting its role in cancer spread. Research is ongoing to understand how kisspeptin can be manipulated for cancer treatment.
Source: ScienceDirect
Studied Memory Enhancement
Certain kisspeptin analogs are important for memory consolidation and orientation in 3-D space. Research in mice suggests these peptides can reverse learning and navigational impairments seen in ethanol intoxication, indicating potential for kisspeptin in offsetting learning deficits in genetic and chronic disease situations.
Impact on Mood
Kisspeptin influences emotion and behavior, integrating sexual and emotional brain processing with reproduction. In a study of 29 healthy men, kisspeptin administration enhanced limbic brain activity, increasing reward-seeking behavior, drive, and overall mood, suggesting its role in mood and motivation.
Kidney and Heart
Kisspeptin is important in the kidney, with its receptor found throughout the organ, playing a role in glomerular development and vascular response to injury. In cardiovascular research, kisspeptin controls vasoconstriction and cardiac output, influencing vascular function and reducing tumor metastasis.
Kisspeptin-10 Summary
Kisspeptin primarily controls hormone secretion related to reproduction, influencing testosterone levels and sex-related behaviors. It also impacts cancer cell growth and metastasis, with research ongoing to understand its therapeutic potential. Kisspeptin-10 shows moderate side effects, good subcutaneous bioavailability in mice, and is for research only.
Kisspeptin-10 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Kisspeptin-10 if you are a licensed researcher.
Packaging
Single vial containing lyophilized product. Each vial contains 6mg Kisspeptin
FAQ
Kisspeptin is a peptide that plays a crucial role in regulating hormone secretion related to human reproduction
Kisspeptin is primarily used to study its effects on reproductive health, energy balance, cancer metastasis suppression, memory enhancement, and mood improvement.
Kisspeptin increases testosterone levels in men by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Disclaimer
This information is not intended to replace professional medical advice. Always consult with a healthcare professional before starting any new supplements.
